Complexation of alkaline earth metals Mg2+, Ca2+, Sr2+ and Ba2+ with adrenaline hormone: Synthesis, spectroscopic and antimicrobial analysis

ABSTRACT. Adrenaline complexes with bivalent ions Mg2+, Ca2+, Sr2+ and Ba2+ in methanol at 60 oC were prepared. The prepared isolated characterized using elemental analyses, conductivity measurements, mid infrared, Raman laser, UV-Vis., 1H–NMR spectra, X-ray powder diffraction, scanning electron microscopy energy-dispersive spectroscopy (EDX). Upon the spectroscopic, stoichiometric reactions indicated 1:2 (M:L) for [Ca(Adr)2(H2O)2](H2O)4Cl2, [Sr(Adr)2(H2O)2]Cl2 [Ba(Adr)2(H2O)6]Cl2 while molar ratio of 1:1 Mg2+ a formula [Mg2(Adr)2(H2O)7]Cl4. interpretation infrared spectra confirmed coordination mode, which was through two-catechol moiety OH phenolic groups. vitro antibacterial activity adrenaline chelates that have been tested against three gram-positive bacteria, two gram-negative strains fungus showed antimicrobial metal are more effective than free ligand.
 
 KEY WORDS: Adrenaline, heavy metals, biological outcomes
 Bull. Chem. Soc. Ethiop. 2023, 37(2), 357-372. DOI: https://dx.doi.org/10.4314/bcse.v37i2.9